产品货号:
Z23979
中文名称:
PD-L1/CD274抗体
英文名称:
Anti-PD-L1/CD274 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-PD-L1/CD274 Antibody |
指标别名 | B7 H;B7 H1;B7 homolog 1;B7H1;CD274;CD274 molecule;PD L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL1;PD-L1;PD-L1/CD274;Programmed death ligand 1 |
克隆性 | Polyclonal |
检验物种 | human |
应用范围 | WB,FCM |
基因名称 | CD274 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | E.coli-derived human PD-L1 recombinant protein (Position:E45-T290).Human PD-L1 shares 69% amino acid (aa) sequence identity with mouse PD-L1. |
实际分子量 | 40~50KD |
成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
纯化方式 | Immunogen affinity purified. |
浓度 | 500μg/mL |
产品形态 | 溶液 |
保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
背景资料 | Programmed death-ligand 1 (PD-L1) also known as CD274 or B7-H1 is a protein that in humans is encoded by the CD274 gene.It is mapped to 9p24.1.PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy,tissue allografts,autoimmune disease and other disease states such as hepatitis.It has been concluded that upregulation of PD-L1 on tumor MDCs downregulates T-cell immunity and that PD-L1 blockade may represent an approach for cancer immunotherapy.PD-L1 can provide positive costimulatory signals for innate and adaptive immunity and for protection against intracellular bacterial infection.What’s more,It has been found that PD1/PDL1 pathway may be a good target for restoring antitumor immunity in ovarian cancer. |
Uniprot ID | Q9NZQ7 |
推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
基因名全称 | CD274 molecule |
蛋白名全称 | Programmed cell death 1 ligand 1 |
推荐稀释比 | Western blot(WB) 1:500~2000 FCM 1~3μg/1×106 cells |
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